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Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b-mediated chromatin demethylation
Mouse
Back Skin
Wounded Whole Cells
scRNA-seq, scATAC-seq
E14.5, E16.5, P5
Male
Quan Phan
Ryan Driskell
Parallel Single-Cell Multiomics Analysis of Neonatal Skin Reveals the Transitional Fibroblast States that Restrict Differentiation into Distinct Fates
Mouse
Back Skin
Wounded Whole Cells
scRNA-seq, scATAC-seq
P0
Male
Sean Thompson
Ryan Driskell
Parallel Single-Cell Multiomics Analysis of Neonatal Skin Reveals the Transitional Fibroblast States that Restrict Differentiation into Distinct Fates
Mouse
Back Skin
Wounded Fibroblast Subset
scRNA-seq, scATAC-seq
P0
Male
Sean Thompson
Ryan Driskell
Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds
Mouse
Back Skin
Whole Cells
scRNAseq
P2-P21
Male
Quan Phan
Ryan Driskell
Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds
Mouse
Back Skin
Fibroblast Subset
scRNA-seq
P2-P21
Male
Quan Phan
Ryan Driskell
Single-cell transcriptomic analysis of small and large wounds reveals the distinct spatial organization of regenerative fibroblasts
Mouse
Back Skin
Wounded Whole Cells
scRNA-seq
P2-P21
Male
Quan Phan
Ryan Driskell
Single-cell transcriptomic analysis of small and large wounds reveals the distinct spatial organization of regenerative fibroblasts
Mouse
Back Skin
Wounded Fibroblast Subset
scRNA-seq
P2-P21
Male
Quan Phan
Ryan Driskell
Excellent single-cell-RNA-seq data from the Kabashima lab.
Human
Trunk and Face
Dissected Eccrine Glands
scRNA-seq
68 years, 74 years, 83 years
Male
Ryan Driskell
Kenji Kabashima
This is a reanalysis of the E18.5 single-cell-RNA-seq analysis from our EMBO paper in 2023.
Mouse
Trunk
Murine Dermal Preparation
scRNA-seq
embryonic day 18.5
Male
Ryan Driskell
Ryan Driskell
A re-analysis of the young timepoint from the Dai Lab, "Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication"
Mouse
Back Skin
Whole Cell
scRNA-seq
7 week
Female
Gitano Hobson
Xing Dai
Post-natal day 5 unsorted dermal preparation performed using 10x genomics.
Mouse
Back skin
Unsorted
Single cell RNA seq
Post-natal day 5
Male
Mason Matich
Ryan Driskell
Reanalysis of e14 skin from our recent publication in EMBO
Murine
Back Skin
Whole Cell
scRNA-seq
e14
Male
Halie Harwood
Ryan Driskell
Epidermis and Dermis tissue from forearm of 22 systemic sclerosis patients and 18 healthy donors prepared as single cell suspension with 10x Genomics.
Human
Forearm Skin
Epidermal & Dermal
Single cell RNA sequence
Varying
Male
Mason Matich
Dr. Johann Gudjonsson