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Lineage commitment of dermal fibroblast progenitors is controlled by Kdm6b-mediated chromatin demethylation
Mouse
Back Skin
Wounded Whole Cells
scRNA-seq, scATAC-seq
E14.5, E16.5, P5
Male
Quan Phan
Ryan Driskell
Parallel Single-Cell Multiomics Analysis of Neonatal Skin Reveals the Transitional Fibroblast States that Restrict Differentiation into Distinct Fates
Mouse
Back Skin
Wounded Whole Cells
scRNA-seq, scATAC-seq
P0
Male
Sean Thompson
Ryan Driskell
Parallel Single-Cell Multiomics Analysis of Neonatal Skin Reveals the Transitional Fibroblast States that Restrict Differentiation into Distinct Fates
Mouse
Back Skin
Wounded Fibroblast Subset
scRNA-seq, scATAC-seq
P0
Male
Sean Thompson
Ryan Driskell
Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds
Mouse
Back Skin
Whole Cells
scRNAseq
P2-P21
Male
Quan Phan
Ryan Driskell
Lef1 expression in fibroblasts maintains developmental potential in adult skin to regenerate wounds
Mouse
Back Skin
Fibroblast Subset
scRNA-seq
P2-P21
Male
Quan Phan
Ryan Driskell
Single-cell transcriptomic analysis of small and large wounds reveals the distinct spatial organization of regenerative fibroblasts
Mouse
Back Skin
Wounded Whole Cells
scRNA-seq
P2-P21
Male
Quan Phan
Ryan Driskell
Single-cell transcriptomic analysis of small and large wounds reveals the distinct spatial organization of regenerative fibroblasts
Mouse
Back Skin
Wounded Fibroblast Subset
scRNA-seq
P2-P21
Male
Quan Phan
Ryan Driskell
A re-analysis of the young timepoint from the Dai Lab, "Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication"
Murine
Back Skin
Whole Cell
scRNA-seq
7 Week
Female
Sam Kindl
Xing Dai
Excellent single-cell-RNA-seq data from the Kabashima lab.
Human
Trunk and Face
Dissected Eccrine Glands
scRNA-seq
68 years, 74 years, 83 years
Male
Ryan Driskell
Kenji Kabashima
This is a reanalysis of the E18.5 single-cell-RNA-seq analysis from our EMBO paper in 2023.
Mouse
Trunk
Murine Dermal Preparation
scRNA-seq
embryonic day 18.5
Male
Ryan Driskell
Ryan Driskell